Somatropin 10IU
Identity
- CAS number
- 12629-01-5
- Molecular formula
- C990H1528N262O300S7
- Molecular weight
- 22124.00
Physical form
- Appearance
- White lyophilised powder
- Purity
- 99%+ (HPLC)
- Solubility
- Soluble in bacteriostatic water
Handling
- Storage
- 2C to 8C, protected from light
- Shelf life
- 24 months from date of manufacture, sealed
Also known as Somatropin, Recombinant human growth hormone, rhGH
Recombinant 191 amino acid polypeptide, 10IU. Refrigerated. Subject to UK regulatory control, read the listing before ordering.
- Dispatch Same day if you order before the cut off, tracked
- Documentation Your batch certificate is emailed when it ships
- Storage 2C to 8C, protected from light
Please note: somatropin is a prescription only medicine in the UK. Please check your own position before ordering, as a research use declaration does not change its legal status.
Product description
Recombinant somatropin, the 191 amino acid polypeptide. Supplied lyophilised as a 10IU vial.
Research context
Somatropin is used in laboratory receptor and assay work as a reference protein. Because it is a large recombinant protein rather than a synthetic peptide, both its handling and its analytical profile differ substantially from the rest of this catalogue.
Handling notes
Refrigerated storage at 2C to 8C rather than frozen. Large recombinant proteins are considerably more sensitive to handling than short synthetic peptides, and agitation, foaming and repeated temperature cycling all cost material. Reconstitute slowly, never shake, and use promptly once in solution.
Worth knowing
This substance is subject to specific regulatory control in the United Kingdom and in many other jurisdictions. Confirm your own legal position before ordering. A research use declaration does not override a national restriction, and we will decline orders where the position is unclear.
Documentation
This batch ships with its own certificate of analysis showing HPLC purity and mass spectrometry identity confirmation. The batch reference is recorded against your order, so a result generated months from now can be traced back to this specific lot.
Intended use
Supplied strictly for laboratory research use. Not a medicine. Not for human or veterinary consumption, and not for any diagnostic or therapeutic use.
Research background
The short version
Recombinant human growth hormone, the full 191 amino acid protein. This is a licensed prescription medicine, not a research peptide, and its regulatory position reflects that.
Somatropin is a recombinant form of the 191 amino acid human growth hormone polypeptide. It is a large protein rather than a synthetic peptide, and both its handling and its analytical profile differ substantially from everything else in this catalogue.
Where it came from
Human growth hormone was characterised in the 1950s. Recombinant production replaced cadaver derived material in the mid 1980s following the transmission of Creutzfeldt-Jakob disease through pituitary extracts, which remains the reason cadaver sourced material is never acceptable.
How it is thought to work
Binds the growth hormone receptor, causing receptor dimerisation and JAK2/STAT5 signalling. Many downstream effects are mediated indirectly through IGF-1 produced in the liver.
As a large recombinant protein it is considerably more sensitive to handling than a short synthetic peptide. Agitation, foaming and temperature cycling all cause measurable loss.
What it is studied for
What the published research found, and what it was tested in. We list the model against each one so you can judge how far the findings go.
- Receptor pharmacology Binding, dimerisation and downstream signalling. What they found Receptor dimerisation and JAK2/STAT5 activation are established. Many downstream effects are mediated indirectly through hepatic IGF-1 rather than directly. Tested in Cell culture
- Assay reference standard Used as a reference protein in immunoassay and bioassay development. What they found Used as a reference protein in immunoassay and bioassay development, where a characterised standard is required. Tested in In vitro
- Protein stability Aggregation and degradation behaviour under handling stress. What they found Aggregation and loss of activity measurable following agitation, foaming or repeated temperature cycling. Tested in In vitro
Specification
| CAS number | 12629-01-5 |
|---|---|
| Molecular formula | C990H1528N262O300S7 |
| Molecular weight | 22124.00 |
| Purity | 99%+ (HPLC) |
| Appearance | White lyophilised powder |
| Solubility | Soluble in bacteriostatic water |
| Storage | 2C to 8C, protected from light |
| Shelf life | 24 months from date of manufacture, sealed |
What you get
- The vial Somatropin 10IU. Sealed and labelled with the compound and its batch reference.
- Certificate of analysis For your batch specifically. Emailed when your order ships and available on this page now.
- Cold chain packaging Gel pack and insulation. We ship these early in the week so nothing sits in a depot over the weekend.
- Plain outer packaging Plain on the outside for your privacy. Everything inside is clearly labelled.
Questions about this compound
How should Somatropin 10IU be stored?
Store the sealed vial at 2C to 8C, protected from light. Sealed and held at that condition it carries a shelf life of 24 months from date of manufacture, sealed from the date of manufacture. Once reconstituted, shelf life shortens considerably and the solution should be aliquoted before freezing rather than thawed repeatedly.
How is Somatropin 10IU reconstituted?
Soluble in bacteriostatic water. Add the solvent slowly down the inside wall of the vial rather than directly onto the material, then swirl gently to dissolve. Do not shake, vortex or sonicate to speed it up. A cloudy solution that will not clear usually means the wrong solvent rather than a poor batch.
What purity is this batch and how is it verified?
This item is supplied at 99%+ (HPLC), measured by high performance liquid chromatography. Identity is confirmed separately by mass spectrometry. Both results appear on the certificate of analysis for the batch you receive, not for a previous lot.
Can I see the certificate of analysis before ordering?
Yes. It is linked in the documentation section of this page. If no certificate is shown against this listing, ask before ordering rather than after.
Is Somatropin 10IU the same as the other names it appears under?
Yes. Somatropin 10IU also appears in the literature as Somatropin, Recombinant human growth hormone, rhGH. They refer to the same compound, which is worth knowing when searching for prior work because results are split across the names.
Can this be used in humans or animals?
No. This is supplied strictly as a laboratory reagent for in vitro research. It is not a medicine, it is not licensed for human or veterinary use, and it should not be administered to a person or an animal. We do not provide dosing or administration guidance.
Handy guides
- Reconstitution and solvents Choosing a solvent, adding it without damaging the peptide, working out concentrations, and the handling errors that cost people a vial.
- Storage and handling Temperature, light, reconstitution and shelf life, and what actually degrades a compound in practice.
- Freeze thaw cycles and shelf life What degrades a peptide in practice, how much a freeze thaw cycle actually costs you, and how to plan aliquots so it stops mattering.
- How to read a certificate of analysis A section by section walkthrough of a peptide certificate: what each figure means, what it does not mean, and the checks worth making before you accept a batch.
