MOTS-c 50mg
Identity
- CAS number
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.62
Physical form
- Appearance
- White lyophilised powder
- Purity
- 99%+ (HPLC)
- Solubility
- Soluble in bacteriostatic water
Handling
- Storage
- -20C, protected from light
- Shelf life
- 24 months from date of manufacture, sealed
Also known as MOTS-c, Mitochondrial ORF of the twelve S rRNA type-c
£46.00
Mitochondrial derived peptide, 16 residues, 10mg lyophilised. Used in metabolic signalling research.
25 in stock
- Dispatch Same day if you order before the cut off, tracked
- Documentation Your batch certificate is emailed when it ships
- Storage -20C, protected from light
Product description
A sixteen amino acid peptide encoded within the mitochondrial genome rather than the nuclear one. Supplied lyophilised in a 10mg vial.
Research context
MOTS-c is unusual in this catalogue in that it is a mitochondrial derived peptide, transcribed from mitochondrial DNA. That origin is what makes it interesting in research on metabolic regulation and on how mitochondria signal to the rest of the cell. Published work covers glucose metabolism, exercise response and mitochondrial stress signalling.
Handling notes
Reconstitute with bacteriostatic water added slowly against the vial wall. Sixteen residues is long enough that the peptide benefits from patience rather than agitation. Store frozen, aliquot after reconstitution.
Worth knowing
The full name, mitochondrial open reading frame of the twelve S rRNA type-c, is almost never used in practice. Searching MOTS-c returns the literature.
Documentation
This batch ships with its own certificate of analysis showing HPLC purity and mass spectrometry identity confirmation. The batch reference is recorded against your order, so a result generated months from now can be traced back to this specific lot.
Intended use
Supplied strictly for laboratory research use. Not a medicine. Not for human or veterinary consumption, and not for any diagnostic or therapeutic use.
Research background
The short version
Unusual because it is encoded in mitochondrial DNA rather than in the cell nucleus. Research treats it as a signal that mitochondria send to the rest of the cell about metabolic state.
MOTS-c is a sixteen amino acid peptide encoded within the mitochondrial genome. That origin is the reason for the research interest: it is evidence that mitochondria participate in signalling rather than only in energy production.
Where it came from
Identified in 2015 by Lee and colleagues at the University of Southern California, working on short open reading frames within mitochondrial DNA. It is one of a small set of mitochondrial derived peptides described since.
How it is thought to work
Proposed to act on the folate and purine biosynthesis pathway, with downstream activation of AMPK, a central sensor of cellular energy state.
Some work reports MOTS-c translocating to the nucleus under metabolic stress and influencing transcription there, which would make it a genuine retrograde signal from mitochondria to nucleus.
What it is studied for
What the published research found, and what it was tested in. We list the model against each one so you can judge how far the findings go.
- Metabolic regulation Glucose handling and insulin sensitivity in cell and animal models. What they found AMPK activation and improved glucose handling reported in cell and rodent models, with effects on insulin sensitivity in diet challenged mice. Tested in Cell culture, rodent models
- Exercise response Whether endogenous MOTS-c changes with physical activity, and what that implies about its role. What they found Endogenous MOTS-c levels reported to change with physical activity in human observational work, which is suggestive of a physiological role rather than demonstrative of one. Tested in Human observational, rodent models
- Mitochondrial retrograde signalling Nuclear translocation and transcriptional effects under stress. What they found Nuclear translocation observed under metabolic stress in cultured cells, with associated transcriptional changes. Tested in Cell culture
Further reading
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis Read the paper
Specification
| CAS number | 1627580-64-6 |
|---|---|
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.62 |
| Purity | 99%+ (HPLC) |
| Appearance | White lyophilised powder |
| Solubility | Soluble in bacteriostatic water |
| Storage | -20C, protected from light |
| Shelf life | 24 months from date of manufacture, sealed |
What you get
- The vial MOTS-c 50mg. Sealed and labelled with the compound and its batch reference.
- Certificate of analysis For your batch specifically. Emailed when your order ships and available on this page now.
- Cold chain packaging Gel pack and insulation. We ship these early in the week so nothing sits in a depot over the weekend.
- Plain outer packaging Plain on the outside for your privacy. Everything inside is clearly labelled.
How it compares
How this compares to the compounds people usually weigh it against. Only the specs that actually differ are shown.
| Specification | SS-31 10mg | This product MOTS-c 50mg | NAD+ 1000mg |
|---|---|---|---|
| Molecular weight | 639.79 | 2174.62 | 663.43 |
| Solubility | Soluble in bacteriostatic water | Soluble in bacteriostatic water | Soluble in water |
| Storage | -20C, protected from light | -20C, protected from light | 2C to 8C, protected from light |
| Price | £58.00 | £46.00 | £42.00 |
Questions about this compound
How should MOTS-c 50mg be stored?
Store the sealed vial at -20C, protected from light. Sealed and held at that condition it carries a shelf life of 24 months from date of manufacture, sealed from the date of manufacture. Once reconstituted, shelf life shortens considerably and the solution should be aliquoted before freezing rather than thawed repeatedly.
How is MOTS-c 50mg reconstituted?
Soluble in bacteriostatic water. Add the solvent slowly down the inside wall of the vial rather than directly onto the material, then swirl gently to dissolve. Do not shake, vortex or sonicate to speed it up. A cloudy solution that will not clear usually means the wrong solvent rather than a poor batch.
What purity is this batch and how is it verified?
This item is supplied at 99%+ (HPLC), measured by high performance liquid chromatography. Identity is confirmed separately by mass spectrometry. Both results appear on the certificate of analysis for the batch you receive, not for a previous lot.
Can I see the certificate of analysis before ordering?
Yes. It is linked in the documentation section of this page. If no certificate is shown against this listing, ask before ordering rather than after.
Is MOTS-c 50mg the same as the other names it appears under?
Yes. MOTS-c 50mg also appears in the literature as MOTS-c, Mitochondrial ORF of the twelve S rRNA type-c. They refer to the same compound, which is worth knowing when searching for prior work because results are split across the names.
Can this be used in humans or animals?
No. This is supplied strictly as a laboratory reagent for in vitro research. It is not a medicine, it is not licensed for human or veterinary use, and it should not be administered to a person or an animal. We do not provide dosing or administration guidance.
Handy guides
- Reconstitution and solvents Choosing a solvent, adding it without damaging the peptide, working out concentrations, and the handling errors that cost people a vial.
- Storage and handling Temperature, light, reconstitution and shelf life, and what actually degrades a compound in practice.
- Freeze thaw cycles and shelf life What degrades a peptide in practice, how much a freeze thaw cycle actually costs you, and how to plan aliquots so it stops mattering.
- How to read a certificate of analysis A section by section walkthrough of a peptide certificate: what each figure means, what it does not mean, and the checks worth making before you accept a batch.
