Epitalon 10mg
Identity
- CAS number
- 307297-39-8
- Molecular formula
- C14H22N4O9
- Molecular weight
- 390.35
Physical form
- Appearance
- White lyophilised powder
- Purity
- 99%+ (HPLC)
- Solubility
- Soluble in bacteriostatic water
Handling
- Storage
- -20C, protected from light
- Shelf life
- 24 months from date of manufacture, sealed
Also known as Epithalon, Epithalamin, AEDG peptide
£28.00
Ala-Glu-Asp-Gly tetrapeptide, 10mg lyophilised. Used in telomerase and cellular senescence work. Also known as Epithalon.
25 in stock
- Dispatch Same day if you order before the cut off, tracked
- Documentation Your batch certificate is emailed when it ships
- Storage -20C, protected from light
Worth knowing: much of the Epitalon research comes from a small number of Russian groups and is not widely available in English, so the evidence base is narrower than for some other compounds here.
Product description
A synthetic tetrapeptide, Ala-Glu-Asp-Gly, developed from research into pineal peptide preparations. Supplied lyophilised in a 10mg vial.
Research context
Epitalon appears in laboratory work on telomerase activity and cellular senescence markers. Much of the foundational research originates from Russian institutes and is not always available in English, which is worth knowing before a literature review. At four amino acids it is one of the shortest peptides in the catalogue.
Handling notes
Reconstitute with bacteriostatic water. Short peptides dissolve quickly and Epitalon is no exception. Store the sealed vial frozen and away from light. Its short sequence does not make it more robust in solution, so aliquot after reconstitution as you would with anything else here.
Worth knowing
Also appears in the literature as Epithalon, Epithalamin and as the AEDG peptide. All four refer to the same tetrapeptide, which makes searching for prior work more difficult than it should be.
Documentation
This batch ships with its own certificate of analysis showing HPLC purity and mass spectrometry identity confirmation. The batch reference is recorded against your order, so a result generated months from now can be traced back to this specific lot.
Intended use
Supplied strictly for laboratory research use. Not a medicine. Not for human or veterinary consumption, and not for any diagnostic or therapeutic use.
Research background
The short version
A four amino acid peptide studied for its effects on telomerase, the enzyme that maintains the protective caps on the ends of chromosomes. Most of the research is Russian and dates from the 1990s onward.
Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly, developed from work on pineal gland peptide preparations. It is one of the shortest sequences in the catalogue and among the most difficult to research properly, because a large share of the primary literature is in Russian and not indexed in the usual databases.
Where it came from
Developed at the Saint Petersburg Institute of Bioregulation and Gerontology from earlier work on Epithalamin, a pineal extract. The synthetic tetrapeptide was intended to reproduce the active fraction.
How it is thought to work
Proposed to influence telomerase activity, which would in turn affect telomere length across cell divisions. The mechanism by which a four residue peptide would achieve this is not established.
Some work proposes effects on melatonin rhythm via the pineal axis, reflecting the compound's origin.
What it is studied for
What the published research found, and what it was tested in. We list the model against each one so you can judge how far the findings go.
- Telomerase activity Effects on telomerase expression and telomere length in dividing cells. What they found Increased telomerase activity and telomere elongation reported in cultured human somatic cells. The primary work is from a small number of groups and has not been widely replicated. Tested in Human somatic cell culture
- Cellular senescence Whether treated cell populations reach replicative senescence at different points. What they found Extended replicative capacity reported in treated cell populations against controls. Tested in Cell culture
- Circadian and pineal function Follows from the compound's derivation from pineal extract. What they found Effects on melatonin rhythm reported in rodent models, consistent with the compound's derivation from pineal extract. Tested in Rodent models
Specification
| CAS number | 307297-39-8 |
|---|---|
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.35 |
| Purity | 99%+ (HPLC) |
| Appearance | White lyophilised powder |
| Solubility | Soluble in bacteriostatic water |
| Storage | -20C, protected from light |
| Shelf life | 24 months from date of manufacture, sealed |
What you get
- The vial Epitalon 10mg. Sealed and labelled with the compound and its batch reference.
- Certificate of analysis For your batch specifically. Emailed when your order ships and available on this page now.
- Cold chain packaging Gel pack and insulation. We ship these early in the week so nothing sits in a depot over the weekend.
- Plain outer packaging Plain on the outside for your privacy. Everything inside is clearly labelled.
Questions about this compound
How should Epitalon 10mg be stored?
Store the sealed vial at -20C, protected from light. Sealed and held at that condition it carries a shelf life of 24 months from date of manufacture, sealed from the date of manufacture. Once reconstituted, shelf life shortens considerably and the solution should be aliquoted before freezing rather than thawed repeatedly.
How is Epitalon 10mg reconstituted?
Soluble in bacteriostatic water. Add the solvent slowly down the inside wall of the vial rather than directly onto the material, then swirl gently to dissolve. Do not shake, vortex or sonicate to speed it up. A cloudy solution that will not clear usually means the wrong solvent rather than a poor batch.
What purity is this batch and how is it verified?
This item is supplied at 99%+ (HPLC), measured by high performance liquid chromatography. Identity is confirmed separately by mass spectrometry. Both results appear on the certificate of analysis for the batch you receive, not for a previous lot.
Can I see the certificate of analysis before ordering?
Yes. It is linked in the documentation section of this page. If no certificate is shown against this listing, ask before ordering rather than after.
Is Epitalon 10mg the same as the other names it appears under?
Yes. Epitalon 10mg also appears in the literature as Epithalon, Epithalamin, AEDG peptide. They refer to the same compound, which is worth knowing when searching for prior work because results are split across the names.
Can this be used in humans or animals?
No. This is supplied strictly as a laboratory reagent for in vitro research. It is not a medicine, it is not licensed for human or veterinary use, and it should not be administered to a person or an animal. We do not provide dosing or administration guidance.
Handy guides
- Reconstitution and solvents Choosing a solvent, adding it without damaging the peptide, working out concentrations, and the handling errors that cost people a vial.
- Storage and handling Temperature, light, reconstitution and shelf life, and what actually degrades a compound in practice.
- Freeze thaw cycles and shelf life What degrades a peptide in practice, how much a freeze thaw cycle actually costs you, and how to plan aliquots so it stops mattering.
- How to read a certificate of analysis A section by section walkthrough of a peptide certificate: what each figure means, what it does not mean, and the checks worth making before you accept a batch.
