SS-31 10mg
Identity
- CAS number
- 736992-21-5
- Molecular formula
- C32H49N9O5
- Molecular weight
- 639.79
Physical form
- Appearance
- White lyophilised powder
- Purity
- 99%+ (HPLC)
- Solubility
- Soluble in bacteriostatic water
Handling
- Storage
- -20C, protected from light
- Shelf life
- 24 months from date of manufacture, sealed
Also known as Elamipretide, MTP-131, Bendavia
£58.00
Cardiolipin targeted tetrapeptide, 10mg lyophilised. Also known as elamipretide and MTP-131.
25 in stock
- Dispatch Same day if you order before the cut off, tracked
- Documentation Your batch certificate is emailed when it ships
- Storage -20C, protected from light
Product description
A synthetic tetrapeptide with selective affinity for cardiolipin in the inner mitochondrial membrane. Supplied lyophilised in a 10mg vial.
Research context
SS-31 is one of the few compounds in this catalogue with a genuinely specific molecular target. Its affinity for cardiolipin means research using it concentrates on mitochondrial bioenergetics, cristae structure and the oxidative stress that follows from membrane disruption. It also appears in the literature as elamipretide and as MTP-131, so a search on one name misses most of the work.
Handling notes
Reconstitute with bacteriostatic water. Store frozen and protected from light. The compound is used at low working concentrations in most published protocols, which makes accurate aliquoting more important than it is with the bulk compounds, and makes a 10mg vial go a long way.
Worth knowing
The naming is the practical problem here. SS-31, elamipretide and MTP-131 are the same peptide, and prior work is split across all three names.
Documentation
This batch ships with its own certificate of analysis showing HPLC purity and mass spectrometry identity confirmation. The batch reference is recorded against your order, so a result generated months from now can be traced back to this specific lot.
Intended use
Supplied strictly for laboratory research use. Not a medicine. Not for human or veterinary consumption, and not for any diagnostic or therapeutic use.
Research background
The short version
One of the few compounds here with a genuinely specific target. It binds to cardiolipin, a fat found only in the inner membrane of mitochondria, which is why research on it concentrates on mitochondrial function.
SS-31 is a synthetic tetrapeptide with selective affinity for cardiolipin in the inner mitochondrial membrane. That specificity distinguishes it from most peptides in this catalogue, where mechanisms are inferred rather than defined, and it is why the compound reached clinical development under the name elamipretide.
Where it came from
Developed from the Szeto-Schiller series of cell permeable antioxidant peptides. Progressed through clinical trials as elamipretide, also referenced as MTP-131 and Bendavia.
How it is thought to work
Cardiolipin is confined to the inner mitochondrial membrane and is essential to the organisation of the electron transport chain. SS-31 associates with it and is proposed to stabilise cristae architecture.
The downstream account is that better organised cristae support more efficient electron transport and less electron leak, which would reduce reactive oxygen species production. That is the proposed chain rather than a demonstrated one at every step.
What it is studied for
What the published research found, and what it was tested in. We list the model against each one so you can judge how far the findings go.
- Mitochondrial bioenergetics Effects on respiration rate, ATP production and cristae structure. What they found Association with cardiolipin, with reported stabilisation of cristae architecture and improved measured respiration in isolated mitochondria. Tested in Isolated mitochondria, cell culture
- Oxidative stress Reactive oxygen species production under experimental stress. What they found Reduced reactive oxygen species production under experimental stress in cell and rodent models. Tested in Cell culture, rodent models
- Clinical development Progressed to human trials as elamipretide in mitochondrial disease, with mixed results across endpoints. What they found Progressed to human trials as elamipretide in primary mitochondrial myopathy. Results were mixed across endpoints, with some measures improving and primary endpoints not consistently met. Tested in Human clinical trials
Further reading
- Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury Read the paper
Specification
| CAS number | 736992-21-5 |
|---|---|
| Molecular formula | C32H49N9O5 |
| Molecular weight | 639.79 |
| Purity | 99%+ (HPLC) |
| Appearance | White lyophilised powder |
| Solubility | Soluble in bacteriostatic water |
| Storage | -20C, protected from light |
| Shelf life | 24 months from date of manufacture, sealed |
What you get
- The vial SS-31 10mg. Sealed and labelled with the compound and its batch reference.
- Certificate of analysis For your batch specifically. Emailed when your order ships and available on this page now.
- Cold chain packaging Gel pack and insulation. We ship these early in the week so nothing sits in a depot over the weekend.
- Plain outer packaging Plain on the outside for your privacy. Everything inside is clearly labelled.
How it compares
How this compares to the compounds people usually weigh it against. Only the specs that actually differ are shown.
| Specification | This product SS-31 10mg | MOTS-c 50mg | NAD+ 1000mg |
|---|---|---|---|
| Molecular weight | 639.79 | 2174.62 | 663.43 |
| Solubility | Soluble in bacteriostatic water | Soluble in bacteriostatic water | Soluble in water |
| Storage | -20C, protected from light | -20C, protected from light | 2C to 8C, protected from light |
| Price | £58.00 | £46.00 | £42.00 |
Questions about this compound
How should SS-31 10mg be stored?
Store the sealed vial at -20C, protected from light. Sealed and held at that condition it carries a shelf life of 24 months from date of manufacture, sealed from the date of manufacture. Once reconstituted, shelf life shortens considerably and the solution should be aliquoted before freezing rather than thawed repeatedly.
How is SS-31 10mg reconstituted?
Soluble in bacteriostatic water. Add the solvent slowly down the inside wall of the vial rather than directly onto the material, then swirl gently to dissolve. Do not shake, vortex or sonicate to speed it up. A cloudy solution that will not clear usually means the wrong solvent rather than a poor batch.
What purity is this batch and how is it verified?
This item is supplied at 99%+ (HPLC), measured by high performance liquid chromatography. Identity is confirmed separately by mass spectrometry. Both results appear on the certificate of analysis for the batch you receive, not for a previous lot.
Can I see the certificate of analysis before ordering?
Yes. It is linked in the documentation section of this page. If no certificate is shown against this listing, ask before ordering rather than after.
Is SS-31 10mg the same as the other names it appears under?
Yes. SS-31 10mg also appears in the literature as Elamipretide, MTP-131, Bendavia. They refer to the same compound, which is worth knowing when searching for prior work because results are split across the names.
Can this be used in humans or animals?
No. This is supplied strictly as a laboratory reagent for in vitro research. It is not a medicine, it is not licensed for human or veterinary use, and it should not be administered to a person or an animal. We do not provide dosing or administration guidance.
Handy guides
- Reconstitution and solvents Choosing a solvent, adding it without damaging the peptide, working out concentrations, and the handling errors that cost people a vial.
- Storage and handling Temperature, light, reconstitution and shelf life, and what actually degrades a compound in practice.
- Freeze thaw cycles and shelf life What degrades a peptide in practice, how much a freeze thaw cycle actually costs you, and how to plan aliquots so it stops mattering.
- How to read a certificate of analysis A section by section walkthrough of a peptide certificate: what each figure means, what it does not mean, and the checks worth making before you accept a batch.
