Glutathione 600mg
Identity
- CAS number
- 70-18-8
- Molecular formula
- C10H17N3O6S
- Molecular weight
- 307.32
Physical form
- Appearance
- White lyophilised powder
- Purity
- 99%+ (HPLC)
- Solubility
- Freely soluble in water
Handling
- Storage
- 2C to 8C, protected from light
- Shelf life
- 24 months from date of manufacture, sealed
Also known as GSH, L-Glutathione reduced, Reduced glutathione
£26.00
Reduced glutathione tripeptide, 600mg. Oxidises on air exposure, prepare solutions fresh.
25 in stock
- Dispatch Same day if you order before the cut off, tracked
- Documentation Your batch certificate is emailed when it ships
- Storage 2C to 8C, protected from light
Product description
Reduced glutathione, the tripeptide Glu-Cys-Gly and the principal intracellular antioxidant in most cell types. Supplied as a 600mg vial.
Research context
Glutathione appears across laboratory work on oxidative stress, redox balance and the detoxification pathways that depend on it. The ratio of reduced to oxidised glutathione is a standard readout in redox research, which makes the reduced form supplied here the one most protocols specify.
Handling notes
The cysteine residue is the practical issue. Glutathione oxidises on exposure to air, so the vial should be kept sealed until use and any solution prepared fresh rather than stored. Refrigerated storage at 2C to 8C, protected from light. It is freely water soluble and dissolves immediately.
Worth knowing
Specify reduced glutathione, or GSH, rather than simply glutathione when writing up, since the oxidised form GSSG behaves differently and the terms are used loosely in the literature.
Documentation
This batch ships with its own certificate of analysis showing HPLC purity and mass spectrometry identity confirmation. The batch reference is recorded against your order, so a result generated months from now can be traced back to this specific lot.
Intended use
Supplied strictly for laboratory research use. Not a medicine. Not for human or veterinary consumption, and not for any diagnostic or therapeutic use.
Research background
The short version
The cell's main internal antioxidant. Researchers usually measure the ratio between its used and unused forms as an indicator of how much oxidative stress a cell is under.
Glutathione is a tripeptide, Glu-Cys-Gly, and the principal intracellular antioxidant across most cell types. The ratio of reduced to oxidised forms is a standard readout in redox biology, which is why the reduced form is what most protocols specify.
Where it came from
Isolated in the 1880s and structurally characterised in the 1930s. It is among the most thoroughly studied small molecules in biochemistry.
How it is thought to work
The free thiol on the cysteine residue donates electrons to neutralise reactive species, becoming oxidised glutathione in the process. Glutathione reductase regenerates the reduced form using NADPH.
The practical consequence is that it oxidises readily on air exposure, which is why solutions are prepared fresh rather than stored.
What it is studied for
What the published research found, and what it was tested in. We list the model against each one so you can judge how far the findings go.
- Redox balance The reduced to oxidised ratio as a measure of cellular oxidative state. What they found The reduced to oxidised ratio is an established quantitative measure of cellular oxidative state and is used as such across the field. Tested in Cell culture, tissue homogenates
- Detoxification pathways Conjugation reactions by glutathione S-transferases. What they found Conjugation by glutathione S-transferases is a well characterised phase two detoxification route. Tested in Cell culture, liver preparations
- Oxidative stress models Depletion and repletion experiments in stressed cells. What they found Depletion increases measured susceptibility to oxidative injury in cultured cells, and repletion reverses it. Tested in Cell culture
Specification
| CAS number | 70-18-8 |
|---|---|
| Molecular formula | C10H17N3O6S |
| Molecular weight | 307.32 |
| Purity | 99%+ (HPLC) |
| Appearance | White lyophilised powder |
| Solubility | Freely soluble in water |
| Storage | 2C to 8C, protected from light |
| Shelf life | 24 months from date of manufacture, sealed |
What you get
- The vial Glutathione 600mg. Sealed and labelled with the compound and its batch reference.
- Certificate of analysis For your batch specifically. Emailed when your order ships and available on this page now.
- Cold chain packaging Gel pack and insulation. We ship these early in the week so nothing sits in a depot over the weekend.
- Plain outer packaging Plain on the outside for your privacy. Everything inside is clearly labelled.
How it compares
How this compares to the compounds people usually weigh it against. Only the specs that actually differ are shown.
| Specification | This product Glutathione 600mg | Glutathione 1500mg | NAD+ 1000mg |
|---|---|---|---|
| Molecular weight | 307.32 | 307.32 | 663.43 |
| Solubility | Freely soluble in water | Freely soluble in water | Soluble in water |
| Price | £26.00 | £52.00 | £42.00 |
Questions about this compound
How should Glutathione 600mg be stored?
Store the sealed vial at 2C to 8C, protected from light. Sealed and held at that condition it carries a shelf life of 24 months from date of manufacture, sealed from the date of manufacture. Once reconstituted, shelf life shortens considerably and the solution should be aliquoted before freezing rather than thawed repeatedly.
How is Glutathione 600mg reconstituted?
Freely soluble in water. Add the solvent slowly down the inside wall of the vial rather than directly onto the material, then swirl gently to dissolve. Do not shake, vortex or sonicate to speed it up. A cloudy solution that will not clear usually means the wrong solvent rather than a poor batch.
What purity is this batch and how is it verified?
This item is supplied at 99%+ (HPLC), measured by high performance liquid chromatography. Identity is confirmed separately by mass spectrometry. Both results appear on the certificate of analysis for the batch you receive, not for a previous lot.
Can I see the certificate of analysis before ordering?
Yes. It is linked in the documentation section of this page. If no certificate is shown against this listing, ask before ordering rather than after.
Is Glutathione 600mg the same as the other names it appears under?
Yes. Glutathione 600mg also appears in the literature as GSH, L-Glutathione reduced, Reduced glutathione. They refer to the same compound, which is worth knowing when searching for prior work because results are split across the names.
Can this be used in humans or animals?
No. This is supplied strictly as a laboratory reagent for in vitro research. It is not a medicine, it is not licensed for human or veterinary use, and it should not be administered to a person or an animal. We do not provide dosing or administration guidance.
Handy guides
- Reconstitution and solvents Choosing a solvent, adding it without damaging the peptide, working out concentrations, and the handling errors that cost people a vial.
- Storage and handling Temperature, light, reconstitution and shelf life, and what actually degrades a compound in practice.
- Freeze thaw cycles and shelf life What degrades a peptide in practice, how much a freeze thaw cycle actually costs you, and how to plan aliquots so it stops mattering.
- How to read a certificate of analysis A section by section walkthrough of a peptide certificate: what each figure means, what it does not mean, and the checks worth making before you accept a batch.
